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Andrea Dovizioso mencetak kemenangan ketiganya musim 2018 di MotoGP Misano disusul Marc Marquez ditempat kedua. Jorge Lorenzo jatuh saat balapan menyisakan dua putaran lagi sehingga dia harus merelakan posisinya menjadi milik Marc Marquez.
Marquez dan Lorenzo, terlibat dalam pertarungan yang mendebarkan pada lap – lap akhir, keduanya mulai mendekati Dovizioso pada lima lap terakhir. Dovisioso yang dari awal lomba sudah memimpin, akhirnya mampu menjaga jarak 2,8 detik setelah kecelakaan Lorenzo. Berikut hasil lengkap race MotoGP San Marino Misano 2018:
| Pos | Rider | Team | Bike | Laps | Gap |
|---|---|---|---|---|---|
| 1 | Andrea Dovizioso | Ducati | Ducati | 27 | 42m05.426s |
| 2 | Marc Marquez | Honda | Honda | 27 | 2.822s |
| 3 | Cal Crutchlow | LCR Honda | Honda | 27 | 7.269s |
| 4 | Alex Rins | Suzuki | Suzuki | 27 | 14.687s |
| 5 | Maverick Vinales | Yamaha | Yamaha | 27 | 16.016s |
| 6 | Dani Pedrosa | Honda | Honda | 27 | 17.408s |
| 7 | Valentino Rossi | Yamaha | Yamaha | 27 | 19.086s |
| 8 | Andrea Iannone | Suzuki | Suzuki | 27 | 21.804s |
| 9 | Alvaro Bautista | Aspar Ducati | Ducati | 27 | 23.919s |
| 10 | Johann Zarco | Tech3 Yamaha | Yamaha | 27 | 27.559s |
| 11 | Danilo Petrucci | Pramac Ducati | Ducati | 27 | 30.698s |
| 12 | Franco Morbidelli | MVDS Honda | Honda | 27 | 32.941s |
| 13 | Takaaki Nakagami | LCR Honda | Honda | 27 | 33.461s |
| 14 | Aleix Espargaro | Aprilia | Aprilia | 27 | 35.686s |
| 15 | Michele Pirro | Ducati | Ducati | 27 | 35.812s |
| 16 | Bradley Smith | KTM | KTM | 27 | 46.500s |
| 17 | Jorge Lorenzo | Ducati | Ducati | 27 | 46.614s |
| 18 | Jack Miller | Pramac Ducati | Ducati | 27 | 50.593s |
| 19 | Hafizh Syahrin | Tech3 Yamaha | Yamaha | 27 | 55.168s |
| 20 | Karel Abraham | Aspar Ducati | Ducati | 27 | 1m02.255s |
| 21 | Scott Redding | Aprilia | Aprilia | 27 | 1m09.475s |
| 22 | Thomas Luthi | MVDS Honda | Honda | 27 | 1m12.608s |
| 23 | Christophe Ponsson | Avintia Ducati | Ducati | 26 | 1 Lap |
| – | Stefan Bradl | Honda | Honda | 17 | Retirement |
| – | Pol Espargaro | KTM | KTM | 17 | Retirement |
| – | Xavier Simeon | Avintia Ducati | Ducati | 2 | Retirement |
